Long-term dietary n3 fatty acid prevents aging-related cardiac diastolic and vascular dysfunction

Saeedi Saravi, Seyed Soheil; Bonetti, Nicole R; Vukolic, Ana; Vdovenko, Daria; Lee, Pratintip; Liberale, Luca; Basso, Cristina; Rizzo, Stefania; Akhmedov, Alexander; Lüscher, Thomas F; Camici, Giovanni G; Beer, Jürg H

doi:10.1016/j.vph.2023.107175

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Saeedi Saravi, S. S., Bonetti, N. R., Vukolic, A., Vdovenko, D., Lee, P., Liberale, L., Basso, C., Rizzo, S., Akhmedov, A., Lüscher, T. F., Camici, G. G., & Beer, J. H. (2023). Long-term dietary n3 fatty acid prevents aging-related cardiac diastolic and vascular dysfunction. Vascular Pharmacology, 150, 107175. https://doi.org/10.1016/j.vph.2023.107175

Abstract

Aims: The prevalence of left ventricular (LV) diastolic and vascular dysfunction increases with age, eventually leading to heart failure with preserved ejection fraction (HFpEF). A preventive strategy is an unmet medical need. We and others reported previously on the beneficial effects of omega-3 fatty acid alpha linolenic acid (ALA) on cardiovascular disorders in animal models and translational studies. We now investigate whether long-term dietary ALA could prevent LV diastolic dysfunction and vascular aging in a murine model.

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