Publication: Granulocyte colony-stimulating factor does not affect contusion size, brain edema or cerebrospinal fluid glutamate concentrations in rats following controlled cortical impact
Granulocyte colony-stimulating factor does not affect contusion size, brain edema or cerebrospinal fluid glutamate concentrations in rats following controlled cortical impact
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Sakowitz, O. W., Schardt, C., Neher, M., Stover, J. F., Unterberg, A. W., & Kiening, K. L. (2006). Granulocyte colony-stimulating factor does not affect contusion size, brain edema or cerebrospinal fluid glutamate concentrations in rats following controlled cortical impact. In J. T. Hoff & et al (Eds.), Brain Edema XIII (No. 96; pp. 139–143). Springer. https://doi.org/10.1007/3-211-30714-1_31
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INTRODUCTION: Granulocyte colony-stimulating factor (G-CSF) is an established treatment in the neutropenic host. Usage in head-injured patients at risk for infection may aggravate brain damage. In contrast, evidence of G-CSF neuroprotective effects has been reported in rodent models of focal cerebral ischemia. We investigated effects of G-CSF in acute focal traumatic brain injury (TBI) in rats. METHODS: Thirty-six male Sprague-Dawley rats were anesthetized with 1.2%) to 2.0% isoflurane and subjected to controlled cortical impact injur
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- Sakowitz, O W
- Schardt, C
- Neher, M
- Stover, J F
- Unterberg, A W
- Kiening, K L
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Sakowitz, O. W., Schardt, C., Neher, M., Stover, J. F., Unterberg, A. W., & Kiening, K. L. (2006). Granulocyte colony-stimulating factor does not affect contusion size, brain edema or cerebrospinal fluid glutamate concentrations in rats following controlled cortical impact. In J. T. Hoff & et al (Eds.), Brain Edema XIII (No. 96; pp. 139–143). Springer. https://doi.org/10.1007/3-211-30714-1_31