Publication: MiR-16-5p is frequently down-regulated in astrocytic gliomas and modulates glioma cell proliferation, apoptosis, and response to cytotoxic therapy
MiR-16-5p is frequently down-regulated in astrocytic gliomas and modulates glioma cell proliferation, apoptosis, and response to cytotoxic therapy
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Krell, A., Wolter, M., Stojcheva, N., Hertler, C., Liesenberg, F., Zapatka, M., Weller, M., Malzkorn, B., & Reifenberger, G. (2019). MiR-16-5p is frequently down-regulated in astrocytic gliomas and modulates glioma cell proliferation, apoptosis, and response to cytotoxic therapy. Neuropathology and Applied Neurobiology, 45(6), 441–458. https://doi.org/10.1111/nan.12532
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AIMS Aberrant expression of microRNAs (miRNAs) is frequent in various cancers including gliomas. We aimed to characterize the role of miR-16-5p as a candidate tumour suppressor miRNA in gliomas. METHODS Real-time PCR-based approaches were used for miRNA and mRNA expression profiling of glioma and non-neoplastic brain tissues as well as glioma cell lines. Protein levels were determined by Western blotting. In vitro analyses were performed following overexpression of miR-16-5p, trichostatin A treatment, and siRNA-mediated knock-down of
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- Krell, Anneliese
- Wolter, Marietta
- Stojcheva, Nina
- Hertler, Caroline
- Liesenberg, Franziska
- Zapatka, Marc
- Weller, Michael
- Malzkorn, Bastian
- Reifenberger, Guido
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Krell, A., Wolter, M., Stojcheva, N., Hertler, C., Liesenberg, F., Zapatka, M., Weller, M., Malzkorn, B., & Reifenberger, G. (2019). MiR-16-5p is frequently down-regulated in astrocytic gliomas and modulates glioma cell proliferation, apoptosis, and response to cytotoxic therapy. Neuropathology and Applied Neurobiology, 45(6), 441–458. https://doi.org/10.1111/nan.12532
