Publication: Perfusate-adsorption during ex vivo lung perfusion improves early post-transplant lung function
Perfusate-adsorption during ex vivo lung perfusion improves early post-transplant lung function
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Iskender, I., Arni, S., Maeyashiki, T., Citak, N., Sauer, M., Monné Rodríguez, J. M., Frauenfelder, T., Opitz, I., Weder, W., & Inci, I. (2021). Perfusate-adsorption during ex vivo lung perfusion improves early post-transplant lung function. Journal of Thoracic and Cardiovascular Surgery, 161(2), e109–e121. https://doi.org/10.1016/j.jtcvs.2019.12.128
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Objective: Improvement in ex vivo lung perfusion (EVLP) protocols could increase the number of donors available for transplantation and protect the lungs from primary graft dysfunction. We hypothesize that perfusate adsorption during EVLP reconditions the allograft to ischemia-reperfusion injury after lung transplantation. Methods: Donor pig lungs were preserved for 24h at 4°C, followed by 6h of EVLP according to the Toronto protocol. The perfusate was additionally adsorbed through a CytoSorb adsorber in the treatment group, whereas c
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Iskender, I., Arni, S., Maeyashiki, T., Citak, N., Sauer, M., Monné Rodríguez, J. M., Frauenfelder, T., Opitz, I., Weder, W., & Inci, I. (2021). Perfusate-adsorption during ex vivo lung perfusion improves early post-transplant lung function. Journal of Thoracic and Cardiovascular Surgery, 161(2), e109–e121. https://doi.org/10.1016/j.jtcvs.2019.12.128
