Publication: A selfish genetic element linked to increased lifespan impacts metabolism in female house mice
A selfish genetic element linked to increased lifespan impacts metabolism in female house mice
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Lopes, P. C., & Lindholm, A. K. (2020). A selfish genetic element linked to increased lifespan impacts metabolism in female house mice. Journal of Experimental Biology, 223, jeb212704. https://doi.org/10.1242/jeb.212704
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Gene drive systems can lead to the evolution of traits that further enhance the transmission of the driving element. In gene drive, one allele is transmitted to offspring at a higher frequency than the homologous allele. This has a range of consequences, which generally include a reduction in fitness of the carrier of the driving allele, making such systems “selfish”. The t haplotype is one such driver, found in house mice. It is linked to a reduction in litter size in matings among heterozygous animals, but also to increased lifespan
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- Lopes, Patricia C
- Lindholm, Anna K
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Lopes, P. C., & Lindholm, A. K. (2020). A selfish genetic element linked to increased lifespan impacts metabolism in female house mice. Journal of Experimental Biology, 223, jeb212704. https://doi.org/10.1242/jeb.212704
