Publication: Cell-free hemoglobin and its scavenger proteins: new disease models leading the way to targeted therapies
Cell-free hemoglobin and its scavenger proteins: new disease models leading the way to targeted therapies
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Schaer, D. J., & Buehler, P. W. (2013). Cell-free hemoglobin and its scavenger proteins: new disease models leading the way to targeted therapies. Cold Spring Harbor Perspectives in Medicine, 3, a013433. https://doi.org/10.1101/cshperspect.a013433
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Abstract
Hemoglobin (Hb) has multiple pathophysiologic effects when released into the intravascular space during hemolysis. The extracellular effects of Hb have resulted in novel models of toxicity, which help to explain endothelial dysfunction and cardiovascular complications that accompany genetic hemolytic anemias, malaria, blood transfusion, and atherosclerosis. The majority of models focus on nitric oxide (NO) depletion; however, in local tissue environments, Hb can also act as a pro-oxidant and inflammatory agent. This can alter cellular
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- Schaer, Dominik J
- Buehler, Paul W
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Schaer, D. J., & Buehler, P. W. (2013). Cell-free hemoglobin and its scavenger proteins: new disease models leading the way to targeted therapies. Cold Spring Harbor Perspectives in Medicine, 3, a013433. https://doi.org/10.1101/cshperspect.a013433
