The Munich MIDY Pig Biobank - A unique resource for studying organ crosstalk in diabetes

Blutke, Andreas; Renner, Simone; Flenkenthaler, Florian; Backman, Mattias; Haesner, Serena; Kemter, Elisabeth; Ländström, Erik; Braun-Reichhart, Christina; Albl, Barbara; Streckel, Elisabeth; Rathkolb, Birgit; Prehn, Cornelia; Palladini, Alessandra; Grzybek, Michal; Krebs, Stefan; Bauersachs, Stefan; Bähr, Andrea; Brühschwein, Andreas; Deeg, Cornelia A; De Monte, Erica

doi:10.1016/j.molmet.2017.06.004

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Blutke, A., Renner, S., Flenkenthaler, F., Backman, M., Haesner, S., Kemter, E., Ländström, E., Braun-Reichhart, C., Albl, B., Streckel, E., Rathkolb, B., Prehn, C., Palladini, A., Grzybek, M., Krebs, S., Bauersachs, S., Bähr, A., Brühschwein, A., Deeg, C. A., … et al. (2017). The Munich MIDY Pig Biobank - A unique resource for studying organ crosstalk in diabetes. Molecular Metabolism, 6(8), 931–940. https://doi.org/10.1016/j.molmet.2017.06.004

Abstract

OBJECTIVE: The prevalence of diabetes mellitus and associated complications is steadily increasing. As a resource for studying systemic consequences of chronic insulin insufficiency and hyperglycemia, we established a comprehensive biobank of long-term diabetic INSC94Y transgenic pigs, a model of mutant INS gene-induced diabetes of youth (MIDY), and of wild-type (WT) littermates. METHODS: Female MIDY pigs (n = 4) were maintained with suboptimal insulin treatment for 2 years, together with female WT littermates (n = 5). Plasma insulin,