Publication: Tuning Tetrazole Photochemistry for Protein Ligation and Molecular Imaging
Tuning Tetrazole Photochemistry for Protein Ligation and Molecular Imaging
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Fay, R., & Holland, J. P. (2021). Tuning Tetrazole Photochemistry for Protein Ligation and Molecular Imaging. Chemistry, 27(15), 4893–4897. https://doi.org/10.1002/chem.202100061
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Photochemistry provides a wide range of alternative reagents that hold potential for use in bimolecular functionalisation of proteins. Here, we report the synthesis and characterisation of metal ion binding chelates derivatised with disubstituted tetrazoles for the photoradiochemical labelling of monoclonal antibodies (mAbs). The photophysical properties of tetrazoles featuring extended aromatic systems and auxochromic substituents to tune excitation toward longer wavelengths (365 and 395 nm) were studied. Two photoactivatable chelate
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- Fay, Rachael
- Holland, Jason P
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Fay, R., & Holland, J. P. (2021). Tuning Tetrazole Photochemistry for Protein Ligation and Molecular Imaging. Chemistry, 27(15), 4893–4897. https://doi.org/10.1002/chem.202100061
