Publication: SynCAMs - From axon guidance to neurodevelopmental disorders
SynCAMs - From axon guidance to neurodevelopmental disorders
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Frei, J. A., & Stoeckli, E. T. (2017). SynCAMs - From axon guidance to neurodevelopmental disorders. Molecular and Cellular Neurosciences, 81, 41–48. https://doi.org/10.1016/j.mcn.2016.08.012
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Many cell adhesion molecules are located at synapses but only few of them can be considered synaptic cell adhesion molecules in the strict sense. Besides the Neurexins and Neuroligins, the LRRTMs (leucine rich repeat transmembrane proteins) and the SynCAMs/CADMs can induce synapse formation when expressed in non-neuronal cells and therefore are true synaptic cell adhesion molecules. SynCAMs (synaptic cell adhesion molecules) are a subfamily of the immunoglobulin superfamily of cell adhesion molecules. As suggested by their name, they
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Frei, J. A., & Stoeckli, E. T. (2017). SynCAMs - From axon guidance to neurodevelopmental disorders. Molecular and Cellular Neurosciences, 81, 41–48. https://doi.org/10.1016/j.mcn.2016.08.012