Publication: Extracellular sodium regulates fibroblast growth factor 23 (FGF23) formation
Extracellular sodium regulates fibroblast growth factor 23 (FGF23) formation
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Radvanyi, Z., Yoo, E. J., Kandasamy, P., Salas-Bastos, A., Monnerat, S., Refardt, J., Christ-Crain, M., Hayashi, H., Kondo, Y., Jantsch, J., Rubio-Aliaga, I., Sommer, L., Wagner, C. A., Hediger, M. A., Kwon, H. M., Loffing, J., & Pathare, G. (2024). Extracellular sodium regulates fibroblast growth factor 23 (FGF23) formation. Journal of Biological Chemistry, 300(1), 105480. https://doi.org/10.1016/j.jbc.2023.105480
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The bone-derived hormone fibroblast growth factor-23 (FGF23) has recently received much attention due to its association with chronic kidney disease and cardiovascular disease progression. Extracellular sodium concentration ([Na$^{+}$]) plays a significant role in bone metabolism. Hyponatremia (lower serum [Na$^{+}$]) has recently been shown to be independently associated with FGF23 levels in patients with chronic systolic heart failure. However, nothing is known about the direct impact of [Na$^{+}$
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Radvanyi, Z., Yoo, E. J., Kandasamy, P., Salas-Bastos, A., Monnerat, S., Refardt, J., Christ-Crain, M., Hayashi, H., Kondo, Y., Jantsch, J., Rubio-Aliaga, I., Sommer, L., Wagner, C. A., Hediger, M. A., Kwon, H. M., Loffing, J., & Pathare, G. (2024). Extracellular sodium regulates fibroblast growth factor 23 (FGF23) formation. Journal of Biological Chemistry, 300(1), 105480. https://doi.org/10.1016/j.jbc.2023.105480
