Publication: Optical recording of neuronal activity with a genetically-encoded calcium indicator in anesthetized and freely moving mice
Optical recording of neuronal activity with a genetically-encoded calcium indicator in anesthetized and freely moving mice
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Lütcke, H., Murayama, M., Hahn, T., Margolis, D. J., Astori, S., Meyer zum Alten Borgloh, S., Göbel, W., Yang, Y., Tang, W., Kügler, S., Sprengel, R., Nagai, T., Miyawaki, A., Larkum, M. E., Helmchen, F., & Hasan, M. T. (2010). Optical recording of neuronal activity with a genetically-encoded calcium indicator in anesthetized and freely moving mice. Frontiers in Neural Circuits, 4, 9. https://doi.org/10.3389/fncir.2010.00009
Abstract
Abstract
Abstract
Fluorescent calcium (Ca(2+)) indicator proteins (FCIPs) are promising tools for functional imaging of cellular activity in living animals. However, they have still not reached their full potential for in vivo imaging of neuronal activity due to limitations in expression levels, dynamic range, and sensitivity for reporting action potentials. Here, we report that viral expression of the ratiometric Ca(2+) sensor yellow cameleon 3.60 (YC3.60) in pyramidal neurons of mouse barrel cortex enables in vivo measurement of neuronal activity wit
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- Lütcke, H
- Murayama, M
- Hahn, T
- Margolis, D J
- Astori, S
- Meyer zum Alten Borgloh, S
- Göbel, W
- Yang, Y
- Tang, W
- Kügler, S
- Sprengel, R
- Nagai, T
- Miyawaki, A
- Larkum, M E
- Helmchen, F
- Hasan, M T
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Lütcke, H., Murayama, M., Hahn, T., Margolis, D. J., Astori, S., Meyer zum Alten Borgloh, S., Göbel, W., Yang, Y., Tang, W., Kügler, S., Sprengel, R., Nagai, T., Miyawaki, A., Larkum, M. E., Helmchen, F., & Hasan, M. T. (2010). Optical recording of neuronal activity with a genetically-encoded calcium indicator in anesthetized and freely moving mice. Frontiers in Neural Circuits, 4, 9. https://doi.org/10.3389/fncir.2010.00009
