Publication: Augmented stress-induced alcohol drinking and withdrawal in mice lacking functional natriuretic peptide-A receptors
Augmented stress-induced alcohol drinking and withdrawal in mice lacking functional natriuretic peptide-A receptors
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Mutschler, J., Bilbao, A., von der Goltz, C., Demiralay, C., Jahn, H., Wiedemann, K., Spanagel, R., & Kiefer, F. (2010). Augmented stress-induced alcohol drinking and withdrawal in mice lacking functional natriuretic peptide-A receptors. Alcohol and Alcoholism, 45(1), 13–16. https://doi.org/10.1093/alcalc/agp065
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AIMS: Preclinical and clinical data suggest an involvement of atrial natriuretic peptides (ANP) in alcohol-associated psychopathology. We now present first data on alcohol drinking behaviour in mice lacking a functional natriuretic peptide-A (NPR-A) receptor.
METHODS: NPR-A(-/-) and wild-type mice were given a free choice between water and increasing concentrations of alcohol (2-16%). A forced swim stress was performed thereafter on three consecutive days to investigate stress-induced alcohol drinking. Additionally, neurobehavioural
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- Mutschler, J
- Bilbao, A
- von der Goltz, C
- Demiralay, C
- Jahn, H
- Wiedemann, K
- Spanagel, R
- Kiefer, F
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Mutschler, J., Bilbao, A., von der Goltz, C., Demiralay, C., Jahn, H., Wiedemann, K., Spanagel, R., & Kiefer, F. (2010). Augmented stress-induced alcohol drinking and withdrawal in mice lacking functional natriuretic peptide-A receptors. Alcohol and Alcoholism, 45(1), 13–16. https://doi.org/10.1093/alcalc/agp065
