Biocompatibility and resorption of a brushite calcium phosphate cement

Theiss, Felix; Apelt, Detlef; Brand, Bastian; Kutter, Annette P N; Zlinszky, Katalin; Bohner, Marc; Matter, Sandro; Frei, Christian; Auer, Jörg A; von Rechenberg, Brigitte

doi:10.1016/j.biomaterials.2004.11.056

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Theiss, F., Apelt, D., Brand, B., Kutter, A. P. N., Zlinszky, K., Bohner, M., Matter, S., Frei, C., Auer, J. A., & von Rechenberg, B. (2005). Biocompatibility and resorption of a brushite calcium phosphate cement. Biomaterials, 26(21), 4383–4394. https://doi.org/10.1016/j.biomaterials.2004.11.056

Abstract

A hydraulic calcium phosphate cement with beta-tricalcium phosphate (TCP) granules embedded in a matrix of dicalcium phosphate dihydrate (DCPD) was implanted in experimentally created defects in sheep. One type of defect consisted of a drill hole in the medial femoral condyle. The other, partial metaphyseal defect was located in the proximal aspect of the tibia plateau and was stabilized using a 3.5 mm T-plate. The bone samples of 2 animals each per group were harvested after 2, 4, 6 and 8 weeks. Samples were evaluated for cement reso