Allergen Immunotherapy for the Prevention and Treatment of Asthma

Batard, Thierry; Taillé, Camille; Guilleminault, Laurent; Bozek, Andrzej; Floch, Véronique Bordas‐Le; Pfaar, Oliver; Canonica, Walter G; Akdis, Cezmi; Shamji, Mohamed H; Mascarell, Laurent

doi:10.1111/cea.14575

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Batard, T., Taillé, C., Guilleminault, L., Bozek, A., Floch, V. B., Pfaar, O., Canonica, W. G., Akdis, C., Shamji, M. H., & Mascarell, L. (2025). Allergen Immunotherapy for the Prevention and Treatment of Asthma. Clinical and Experimental Allergy, 55(2), 111–141. https://doi.org/10.1111/cea.14575

Abstract

Allergic asthma is the predominant phenotype among asthmatics. Although conventional pharmacotherapy is a central component in the management of asthma, it does not enable control of asthma symptoms in all patients. In recent decades, some uncontrolled asthmatic patients, especially those with allergic asthma, have benefited from biological therapies. However, biologics do not address all the unmet needs left by conventional pharmacotherapy. Furthermore, it is noteworthy that neither conventional pharmacotherapy nor biological therapi