Publication: Pleiotropic combinatorial transcriptomes of human breast cancer cells exposed to mixtures of dietary phytoestrogens
Pleiotropic combinatorial transcriptomes of human breast cancer cells exposed to mixtures of dietary phytoestrogens
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Dip, R., Lenz, S., Gmuender, H., & Naegeli, H. (2009). Pleiotropic combinatorial transcriptomes of human breast cancer cells exposed to mixtures of dietary phytoestrogens. Food and Chemical Toxicology, 47, 787–795. https://doi.org/10.1016/j.fct.2009.01.008
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Combinations of estrogen receptor agonists have been shown to exert more potent effects than single compounds in many single-endpoint bioassays. However, to our knowledge, it has never been tested how genome-wide expression programs are shaped by the interplay of multiple estrogenic stimuli. In view of the abundance of dietary phytoestrogens, we selected binary mixtures of these phytochemicals to determine their global impact using high-density DNA microarrays. MCF7 cells, a frequent in vitro model for molecular processes associated w
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Dip, R., Lenz, S., Gmuender, H., & Naegeli, H. (2009). Pleiotropic combinatorial transcriptomes of human breast cancer cells exposed to mixtures of dietary phytoestrogens. Food and Chemical Toxicology, 47, 787–795. https://doi.org/10.1016/j.fct.2009.01.008