Publication: Overgrowth caused by misexpression of a microRNA with dispensable wild-type function
Overgrowth caused by misexpression of a microRNA with dispensable wild-type function
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Nairz, K., Rottig, C., Rintelen, F., Zdobnov, E., Moser, M., & Hafen, E. (2006). Overgrowth caused by misexpression of a microRNA with dispensable wild-type function. Developmental Biology, 291(2), 314–324. https://doi.org/10.1016/j.ydbio.2005.11.047
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MicroRNAs (miRNAs) represent an abundant class of non-coding RNAs that negatively regulate gene expression, primarily at the post-transcriptional level. miRNA genes are frequently located in proximity to fragile chromosomal sites associated with cancers and amplification of a miRNA cluster has been correlated with the etiology of lymphomas and solid tumors. The oncogenic potential of a miRNA polycistron has recently been demonstrated in vivo. Here, we show that misexpression of the Drosophila miRNA mirvana/mir-278 in the developing ey
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- Nairz, K
- Rottig, C
- Rintelen, F
- Zdobnov, E
- Moser, M
- Hafen, E
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Nairz, K., Rottig, C., Rintelen, F., Zdobnov, E., Moser, M., & Hafen, E. (2006). Overgrowth caused by misexpression of a microRNA with dispensable wild-type function. Developmental Biology, 291(2), 314–324. https://doi.org/10.1016/j.ydbio.2005.11.047