Publication: Inhibition of mammalian DNA polymerases by resveratrol: mechanism and structural determinants.
Inhibition of mammalian DNA polymerases by resveratrol: mechanism and structural determinants.
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Locatelli, G. A., Savio, M., Forti, L., Shevelev, I., Ramadan, K., Stivala, L. A., Vannini, V., Hübscher, U., Spadari, S., & Maga, G. (2005). Inhibition of mammalian DNA polymerases by resveratrol: mechanism and structural determinants. Biochemical Journal, 389(2), 259–268. https://doi.org/10.1042/BJ20050094
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Resveratrol, a natural compound found in many dietary plants and in red wine, plays an important role in the prevention of many human pathological processes, including inflammation, atherosclerosis and carcinogenesis. We have shown that the antiproliferative activity of resveratrol correlated with its ability to inhibit the replicative pols (DNA polymerases) alpha and delta in vitro [Stivala, Savio, Carafoli, Perucca, Bianchi, Maga, Forti, Pagnoni, Albini, Prosperi and Vannini (2001) J. Biol. Chem. 276, 22586-22594]. In this paper, we
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- Locatelli, G A
- Savio, M
- Forti, L
- Shevelev, I
- Ramadan, K
- Stivala, L A
- Vannini, V
- Hübscher, U
- Spadari, S
- Maga, G
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Locatelli, G. A., Savio, M., Forti, L., Shevelev, I., Ramadan, K., Stivala, L. A., Vannini, V., Hübscher, U., Spadari, S., & Maga, G. (2005). Inhibition of mammalian DNA polymerases by resveratrol: mechanism and structural determinants. Biochemical Journal, 389(2), 259–268. https://doi.org/10.1042/BJ20050094