Publication:

Cross-Coupling Reactions of Monosubstituted Tetrazines

Date

Date

Date
2021
Journal Article
Published version
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cris.lastimport.scopus2025-06-13T03:34:52Z
cris.lastimport.wos2025-07-25T01:33:54Z
cris.virtual.orcidhttps://orcid.org/0000-0003-3053-0689
cris.virtual.orcidhttps://orcid.org/0000-0002-9343-9180
cris.virtualsource.orcid423757d4-b8af-419a-bc08-c425c5c49daa
cris.virtualsource.orcid583798eb-3ab4-47b8-a603-8db9be1b8d4f
dc.contributor.institutionUniversity of Zurich
dc.date.accessioned2022-01-17T16:20:32Z
dc.date.available2022-01-17T16:20:32Z
dc.date.issued2021-08-06
dc.description.abstract

A Ag-mediated Pd-catalyzed cross-coupling method for 3-bromo-1,2,4,5-tetrazine with boronic acids is presented. Electronic modification of the 1,1′-bis(diphenylphosphine)ferrocene (dppf) ligand was found to be crucial for good turnover. Using this fast method, a variety of alkyl-, heteroatom-, and halide-substituted aryl- and heteroaryl-tetrazines were prepared (29 examples, up to 87% yield).

dc.identifier.doi10.1021/acs.orglett.1c01813
dc.identifier.issn1523-7052
dc.identifier.scopus2-s2.0-85112307455
dc.identifier.urihttps://www.zora.uzh.ch/handle/20.500.14742/190926
dc.identifier.wos000684033200019
dc.language.isoeng
dc.subjectOrganic Chemistry
dc.subjectPhysical and Theoretical Chemistry
dc.subjectBiochemistry
dc.subject.ddc540 Chemistry
dc.title

Cross-Coupling Reactions of Monosubstituted Tetrazines

dc.typearticle
dcterms.accessRightsinfo:eu-repo/semantics/openAccess
dcterms.bibliographicCitation.journaltitleOrganic Letters
dcterms.bibliographicCitation.number15
dcterms.bibliographicCitation.originalpublishernameAmerican Chemical Society (ACS)
dcterms.bibliographicCitation.pageend5692
dcterms.bibliographicCitation.pagestart5689
dcterms.bibliographicCitation.volume23
dspace.entity.typePublicationen
uzh.contributor.affiliationUniversity of Zurich
uzh.contributor.affiliationUniversity of Zurich
uzh.contributor.affiliationUniversity of Zurich
uzh.contributor.affiliationUniversity of Zurich
uzh.contributor.affiliationUniversity of Zurich
uzh.contributor.authorHoff, Lukas V
uzh.contributor.authorSchnell, Simon D
uzh.contributor.authorTomio, Andrea
uzh.contributor.authorLinden, Anthony
uzh.contributor.authorGademann, Karl
uzh.contributor.correspondenceNo
uzh.contributor.correspondenceNo
uzh.contributor.correspondenceNo
uzh.contributor.correspondenceNo
uzh.contributor.correspondenceYes
uzh.document.availabilitypostprint
uzh.eprint.datestamp2022-01-17 16:20:32
uzh.eprint.lastmod2025-07-25 01:42:27
uzh.eprint.statusChange2022-01-17 16:20:32
uzh.harvester.ethYes
uzh.harvester.nbNo
uzh.identifier.doi10.5167/uzh-212592
uzh.jdb.eprintsId20837
uzh.oastatus.unpaywallclosed
uzh.oastatus.zoraGreen
uzh.publication.citationHoff, Lukas V; Schnell, Simon D; Tomio, Andrea; Linden, Anthony; Gademann, Karl (2021). Cross-Coupling Reactions of Monosubstituted Tetrazines. Organic Letters, 23(15):5689-5692.
uzh.publication.originalworkoriginal
uzh.publication.publishedStatusfinal
uzh.scopus.impact13
uzh.scopus.subjectsBiochemistry
uzh.scopus.subjectsPhysical and Theoretical Chemistry
uzh.scopus.subjectsOrganic Chemistry
uzh.workflow.doajuzh.workflow.doaj.false
uzh.workflow.eprintid212592
uzh.workflow.fulltextStatuspublic
uzh.workflow.revisions41
uzh.workflow.rightsCheckkeininfo
uzh.workflow.sourceCrossRef:10.1021/acs.orglett.1c01813
uzh.workflow.statusarchive
uzh.wos.impact13
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