Lack of APLP1 leads to subtle alterations in neuronal morphology but does not affect learning and memory

Erdinger, Susanne; Amrein, Irmgard; Back, Michaela; Ludewig, Susann; Korte, Martin; von Engelhardt, Jakob; Wolfer, David P; Müller, Ulrike C

doi:10.5167/uzh-224148

Citations

Citation copied

Erdinger, S., Amrein, I., Back, M., Ludewig, S., Korte, M., von Engelhardt, J., Wolfer, D. P., & Müller, U. C. (2022). Lack of APLP1 leads to subtle alterations in neuronal morphology but does not affect learning and memory. Frontiers in Molecular Neuroscience, 15, 1028836. https://doi.org/10.3389/fnmol.2022.1028836

Abstract

The amyloid precursor protein APP plays a crucial role in Alzheimer pathogenesis. Its physiological functions, however, are only beginning to be unraveled. APP belongs to a small gene family, including besides APP the closely related amyloid precursor-like proteins APLP1 and APLP2, that all constitute synaptic adhesion proteins. While APP and APLP2 are ubiquitously expressed, APLP1 is specific for the nervous system. Previous genetic studies, including combined knockouts of several family members, pointed towards a unique role for APL