Publication: Enhanced IL-6 transcriptional response to adenosine receptor ligands in horses with lower airway inflammation
Enhanced IL-6 transcriptional response to adenosine receptor ligands in horses with lower airway inflammation
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Zhang, L., Franchini, M., Wehrli Eser, M., & Dip, R. (2012). Enhanced IL-6 transcriptional response to adenosine receptor ligands in horses with lower airway inflammation. Equine Veterinary Journal, 44(1), 81–87. https://doi.org/10.1111/j.2042-3306.2010.00350.x
Abstract
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Reasons for performing study: Accumulation of extracellular adenosine has been closely associated with human asthmatic responses. However, the relevance of adenosine signalling in equine airways has not previously been investigated. Objectives: To determine the expression of adenosine receptors (AR) in bronchoalveolar lavage (BAL) cells and assess the reactivity of these cells to AR ligands ex vivo, employing IL-6 as readout of adenosinergic inflammatory signalling. Methods: Eight horses with varying degrees of lower airway inflammati
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- Zhang, L
- Franchini, M
- Wehrli Eser, M
- Dip, R
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Zhang, L., Franchini, M., Wehrli Eser, M., & Dip, R. (2012). Enhanced IL-6 transcriptional response to adenosine receptor ligands in horses with lower airway inflammation. Equine Veterinary Journal, 44(1), 81–87. https://doi.org/10.1111/j.2042-3306.2010.00350.x
