Publication: KPC-50 confers resistance to ceftazidime-avibactam associated with reduced carbapenemase activity
KPC-50 confers resistance to ceftazidime-avibactam associated with reduced carbapenemase activity
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Poirel, L., Vuillemin, X., Juhas, M., Masseron, A., Bechtel-Grosch, U., Tiziani, S., Mancini, S., & Nordmann, P. (2020). KPC-50 confers resistance to ceftazidime-avibactam associated with reduced carbapenemase activity. Antimicrobial Agents and Chemotherapy, 64(8), e00321-20. https://doi.org/10.1128/AAC.00321-20
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KPC-50 is a KPC-3 variant identified from a Klebsiella pneumoniae clinical isolate recovered in Switzerland in 2019. As compared to KPC-3, KPC-50 shows i) a three amino-acid insertion (Glu-Ala-Val) between amino acids 276 and 277 amino acid sequence, (ii) an increased affinity to ceftazidime, (iii) a decreased sensitivity to avibactam, explaining the ceftazidime-avibactam resistance, and (iv) associated to a sharp reduction of its carbapenemase activity.
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Poirel, L., Vuillemin, X., Juhas, M., Masseron, A., Bechtel-Grosch, U., Tiziani, S., Mancini, S., & Nordmann, P. (2020). KPC-50 confers resistance to ceftazidime-avibactam associated with reduced carbapenemase activity. Antimicrobial Agents and Chemotherapy, 64(8), e00321-20. https://doi.org/10.1128/AAC.00321-20
