Publication: Cell-cell transmission enables HIV-1 to evade inhibition by potent CD4bs directed antibodies
Cell-cell transmission enables HIV-1 to evade inhibition by potent CD4bs directed antibodies
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Abela, I. A., Berlinger, L., Schanz, M., Reynell, L., Günthard, H. F., Rusert, P., & Trkola, A. (2012). Cell-cell transmission enables HIV-1 to evade inhibition by potent CD4bs directed antibodies. PLoS Pathogens, 8(4), e1002634. https://doi.org/10.1371/journal.ppat.1002634
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HIV is known to spread efficiently both in a cell-free state and from cell to cell, however the relative importance of the cell-cell transmission mode in natural infection has not yet been resolved. Likewise to what extent cell-cell transmission is vulnerable to inhibition by neutralizing antibodies and entry inhibitors remains to be determined. Here we report on neutralizing antibody activity during cell-cell transmission using specifically tailored experimental strategies which enable unambiguous discrimination between the two trans
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Abela, I. A., Berlinger, L., Schanz, M., Reynell, L., Günthard, H. F., Rusert, P., & Trkola, A. (2012). Cell-cell transmission enables HIV-1 to evade inhibition by potent CD4bs directed antibodies. PLoS Pathogens, 8(4), e1002634. https://doi.org/10.1371/journal.ppat.1002634