Publication: Characterization of the 19q12 amplification including CCNE1 and URI in different epithelial ovarian cancer subtypes
Characterization of the 19q12 amplification including CCNE1 and URI in different epithelial ovarian cancer subtypes
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Noske, A., Henricksen, L. A., LaFleur, B., Zimmermann, A.-K., Tubbs, A., Singh, S., Storz, M., Fink, D., & Moch, H. (2014). Characterization of the 19q12 amplification including CCNE1 and URI in different epithelial ovarian cancer subtypes. Experimental and Molecular Pathology, 98, 47–54. https://doi.org/10.1016/j.yexmp.2014.12.004
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BACKGROUND: CCNE1 is frequently amplified in high grade serous ovarian cancer and may serve as a target for ovarian cancer treatment. URI is closely related to CCNE1 at the 19q12 amplicon and may also contribute to the oncogenic effect. Our objective was to investigate the relevance of CCNE1 and URI gene amplification and protein expression in different histological subtypes of epithelial ovarian cancer (EOC). METHODS: A novel dual-color 19q12 in situ hybridization (ISH), covering CCNE1 and URI, and chromosome 19 as a surrogate using
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- Noske, Aurelia
- Henricksen, Leigh A
- LaFleur, Bonnie
- Zimmermann, Anne-Katrin
- Tubbs, Alisa
- Singh, Shalini
- Storz, Martina
- Fink, Daniel
- Moch, Holger
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Noske, A., Henricksen, L. A., LaFleur, B., Zimmermann, A.-K., Tubbs, A., Singh, S., Storz, M., Fink, D., & Moch, H. (2014). Characterization of the 19q12 amplification including CCNE1 and URI in different epithelial ovarian cancer subtypes. Experimental and Molecular Pathology, 98, 47–54. https://doi.org/10.1016/j.yexmp.2014.12.004
