Ultrasound trapping and navigation of microrobots in the mouse brain vasculature

Del Campo Fonseca, Alexia; Glück, Chaim; Droux, Jeanne; Ferry, Yann; Frei, Carole; Wegener, Susanne; Weber, Bruno; El Amki, Mohamad; Ahmed, Daniel

doi:10.5167/uzh-239413

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Del Campo Fonseca, A., Glück, C., Droux, J., Ferry, Y., Frei, C., Wegener, S., Weber, B., El Amki, M., & Ahmed, D. (2023). Ultrasound trapping and navigation of microrobots in the mouse brain vasculature. Nature Communications, 14, 5889. https://doi.org/10.1038/s41467-023-41557-3

Abstract

The intricate and delicate anatomy of the brain poses significant challenges for the treatment of cerebrovascular and neurodegenerative diseases. Thus, precise local drug delivery in hard-to-reach brain regions remains an urgent medical need. Microrobots offer potential solutions; however, their functionality in the brain remains restricted by limited imaging capabilities and complications within blood vessels, such as high blood flows, osmotic pressures, and cellular responses. Here, we introduce ultrasound-activated microrobots for