Publication: Light-Activated Agonist-Potentiator of GABA$_{A}$ Receptors for Reversible Neuroinhibition in Wildtype Mice
Light-Activated Agonist-Potentiator of GABA$_{A}$ Receptors for Reversible Neuroinhibition in Wildtype Mice
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Maleeva, G., Nin-Hill, A., Wirth, U., Rustler, K., Ranucci, M., Opar, E., Rovira, C., Bregestovski, P., Zeilhofer, H. U., König, B., Alfonso-Prieto, M., & Gorostiza, P. (2024). Light-Activated Agonist-Potentiator of GABA$_{A}$ Receptors for Reversible Neuroinhibition in Wildtype Mice. Journal of the American Chemical Society, 146(42), 28822–28831. https://doi.org/10.1021/jacs.4c08446
Abstract
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Abstract
Gamma aminobutyric acid type A receptors (GABA${A}$Rs) play a key role in the mammalian central nervous system (CNS) as drivers of neuroinhibitory circuits, which are commonly targeted for therapeutic purposes with potentiator drugs. However, due to their widespread expression and strong inhibitory action, systemic pharmaceutical potentiation of GABA${A}$Rs inevitably causes adverse effects regardless of the drug selectivity. Therefore, therapeutic guidelines must often limit or exclude clinically available GABA$_{A}$
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Creators (Authors)
- Maleeva, Galyna
- Nin-Hill, Alba
- Wirth, Ulrike
- Rustler, Karin
- Ranucci, Matteo
- Opar, Ekin
- Rovira, Carme
- Bregestovski, Piotr
- König, Burkhard
- Alfonso-Prieto, Mercedes
- Gorostiza, Pau
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Maleeva, G., Nin-Hill, A., Wirth, U., Rustler, K., Ranucci, M., Opar, E., Rovira, C., Bregestovski, P., Zeilhofer, H. U., König, B., Alfonso-Prieto, M., & Gorostiza, P. (2024). Light-Activated Agonist-Potentiator of GABA$_{A}$ Receptors for Reversible Neuroinhibition in Wildtype Mice. Journal of the American Chemical Society, 146(42), 28822–28831. https://doi.org/10.1021/jacs.4c08446
