Publication: Deoxy-sphingolipids, oxidative stress, and vitamin C correlate with qualitative and quantitative patterns of small fiber dysfunction and degeneration
Deoxy-sphingolipids, oxidative stress, and vitamin C correlate with qualitative and quantitative patterns of small fiber dysfunction and degeneration
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Dohrn, M. F., Dumke, C., Hornemann, T., Nikolin, S., Lampert, A., Espenkott, V., Vollert, J., Ouwenbroek, A., Zanella, M., Schulz, J. B., Gess, B., & Rolke, R. (2022). Deoxy-sphingolipids, oxidative stress, and vitamin C correlate with qualitative and quantitative patterns of small fiber dysfunction and degeneration. Pain, 163(9), 1800–1811. https://doi.org/10.1097/j.pain.0000000000002580
Abstract
Abstract
Abstract
Defined by dysfunction or degeneration of Aδ and C fibers, small fiber neuropathies (SFNs) entail a relevant health burden. In 50% of cases, the underlying cause cannot be identified or treated. In 100 individuals (70% female individuals; mean age: 44.8 years) with an idiopathic, skin biopsy-confirmed SFN, we characterized the symptomatic spectrum and measured markers of oxidative stress (vitamin C, selenium, and glutathione) and inflammation (transforming growth factor beta, tumor necrosis factor alpha), as well as neurotoxic 1-deoxy
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- Dohrn, Maike F
- Dumke, Christina
- Hornemann, Thorsten
- Nikolin, Stefan
- Lampert, Angelika
- Espenkott, Volker
- Vollert, Jan
- Ouwenbroek, Annabelle
- Zanella, Martina
- Schulz, Jörg B
- Gess, Burkhard
- Rolke, Roman
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Dohrn, M. F., Dumke, C., Hornemann, T., Nikolin, S., Lampert, A., Espenkott, V., Vollert, J., Ouwenbroek, A., Zanella, M., Schulz, J. B., Gess, B., & Rolke, R. (2022). Deoxy-sphingolipids, oxidative stress, and vitamin C correlate with qualitative and quantitative patterns of small fiber dysfunction and degeneration. Pain, 163(9), 1800–1811. https://doi.org/10.1097/j.pain.0000000000002580
