Neurostructural traces of early life adversities: A meta-analysis exploring age- and adversity-specific effects

Pollok, Tania M; Kaiser, Anna; Kraaijenvanger, Eline J; Monninger, Maximilian; Brandeis, Daniel; Banaschewski, Tobias; Eickhoff, Simon B; Holz, Nathalie E

doi:10.5167/uzh-219862

Citations

Citation copied

Pollok, T. M., Kaiser, A., Kraaijenvanger, E. J., Monninger, M., Brandeis, D., Banaschewski, T., Eickhoff, S. B., & Holz, N. E. (2022). Neurostructural traces of early life adversities: A meta-analysis exploring age- and adversity-specific effects. Neuroscience and Biobehavioral Reviews, 135, 104589. https://doi.org/10.1016/j.neubiorev.2022.104589

Abstract

Early life adversities (ELAs) are associated with an increased risk of psychopathology, with studies suggesting a relation to structural brain alterations. Given the recently growing evidence of ELA effects on brain structure, an updated summary is highly warranted. Therefore, anatomical likelihood estimation was used to conduct a coordinate-based meta-analysis of gray matter volume (GMV) alterations associated with ELAs, including sub-analyses for different age groups and maltreatment as specific ELA-type. The analyses uncovered a co