Structural and Functional Studies of Large-Pore Channels of the CALHM Family

Abstract

A cell relies on proteins, termed ion channels, that facilitate the passage of ions across its membranes. These channels contain pores that activate in response to certain stimuli, allowing ion flow in their open state. Previous research has predominantly focused on ion channels with narrow and selective pores, which permit only certain types of inorganic ions to cross the membrane. However, there is increasing interest in proteins that form channels with wider pores that facilitate the permeation of larger substrates. These large-por Show more