Publication: Endemic Burkitt lymphoma avatar mouse models for exploring inter-patient tumor variation and testing targeted therapies
Endemic Burkitt lymphoma avatar mouse models for exploring inter-patient tumor variation and testing targeted therapies
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Saikumar Lakshmi, P., Oduor, C. I., Forconi, C. S., M’Bana, V., Bly, C., Gerstein, R. M., Otieno, J. A., Ong’echa, J. M., Münz, C., Luftig, M. A., Brehm, M. A., Bailey, J. A., & Moormann, A. M. (2023). Endemic Burkitt lymphoma avatar mouse models for exploring inter-patient tumor variation and testing targeted therapies. Life Science Alliance, 6(5), e202101355. https://doi.org/10.26508/lsa.202101355
Abstract
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Abstract
Endemic Burkitt lymphoma (BL) is a childhood cancer in sub-Saharan Africa characterized by Epstein-Barr virus and malaria-associated aberrant B-cell activation and MYC chromosomal translocation. Survival rates hover at 50% after conventional chemotherapies; therefore, clinically relevant models are necessary to test additional therapies. Hence, we established five patient-derived BL tumor cell lines and corresponding NSG-BL avatar mouse models. Transcriptomics confirmed that our BL lines maintained fidelity from patient tumors to NSG-
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- Saikumar Lakshmi, Priya
- Oduor, Cliff I
- Forconi, Catherine S
- M'Bana, Viriato
- Bly, Courtney
- Gerstein, Rachel M
- Otieno, Juliana A
- Ong'echa, John M
- Münz, Christian
- Luftig, Micah A
- Brehm, Michael A
- Bailey, Jeffrey A
- Moormann, Ann M
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Saikumar Lakshmi, P., Oduor, C. I., Forconi, C. S., M’Bana, V., Bly, C., Gerstein, R. M., Otieno, J. A., Ong’echa, J. M., Münz, C., Luftig, M. A., Brehm, M. A., Bailey, J. A., & Moormann, A. M. (2023). Endemic Burkitt lymphoma avatar mouse models for exploring inter-patient tumor variation and testing targeted therapies. Life Science Alliance, 6(5), e202101355. https://doi.org/10.26508/lsa.202101355
