Publication: Hypoxia positively regulates the expression of pH-sensing G-protein-coupled receptor OGR1 (GPR68)
Hypoxia positively regulates the expression of pH-sensing G-protein-coupled receptor OGR1 (GPR68)
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de Vallière, C., Cosin-Roger, J., Simmen, S., Atrott, K., Melhem, H., Zeitz, J., Madanchi, M., Tcymbarevich, I., Fried, M., Kullak-Ublick, G. A., Vavricka, S. R., Misselwitz, B., Seuwen, K., Wagner, C. A., Eloranta, J. J., Rogler, G., & Ruiz, P. A. (2016). Hypoxia positively regulates the expression of pH-sensing G-protein-coupled receptor OGR1 (GPR68). Cellular and Molecular Gastroenterology and Hepatology, 2(6), 796–810. https://doi.org/10.1016/j.jcmgh.2016.06.003
Abstract
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BACKGROUND & AIMS A novel family of proton-sensing G-protein-coupled receptors, including ovarian cancer G-protein-coupled receptor 1 (OGR1) (GPR68) has been identified to play a role in pH homeostasis. Hypoxia is known to change tissue pH as a result of anaerobic glucose metabolism through the stabilization of hypoxia-inducible factor-1α. We investigated how hypoxia regulates the expression of OGR1 in the intestinal mucosa and associated cells. METHODS OGR1 expression in murine tumors, human colonic tissue, and myeloid cells was dete
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Creators (Authors)
- de Vallière, Cheryl
- Cosin-Roger, Jesus
- Simmen, Simona
- Atrott, Kirstin
- Melhem, Hassan
- Zeitz, Jonas
- Madanchi, Mehdi
- Tcymbarevich, Irina
- Fried, Michael
- Kullak-Ublick, Gerd A
- Vavricka, Stephan R
- Misselwitz, Benjamin
- Seuwen, Klaus
- Wagner, Carsten A
- Eloranta, Jyrki J
- Rogler, Gerhard
- Ruiz, Pedro A
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de Vallière, C., Cosin-Roger, J., Simmen, S., Atrott, K., Melhem, H., Zeitz, J., Madanchi, M., Tcymbarevich, I., Fried, M., Kullak-Ublick, G. A., Vavricka, S. R., Misselwitz, B., Seuwen, K., Wagner, C. A., Eloranta, J. J., Rogler, G., & Ruiz, P. A. (2016). Hypoxia positively regulates the expression of pH-sensing G-protein-coupled receptor OGR1 (GPR68). Cellular and Molecular Gastroenterology and Hepatology, 2(6), 796–810. https://doi.org/10.1016/j.jcmgh.2016.06.003
