Publication: Controlled Oxygen Release from Pyridone Endoperoxides Promotes Cell Survival under Anoxic Conditions
Controlled Oxygen Release from Pyridone Endoperoxides Promotes Cell Survival under Anoxic Conditions
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Benz, S., Noetzli, S., Siegel, J. S., Eberli, D., & Jessen, H. J. (2013). Controlled Oxygen Release from Pyridone Endoperoxides Promotes Cell Survival under Anoxic Conditions. Journal of Medicinal Chemistry, 56(24), 10171–10182. https://doi.org/10.1021/jm4016137
Abstract
Abstract
Abstract
In tissue engineering, survival of larger constructs remains challenging due to limited supply with oxygen caused by a lack of early vascularization. Controlled release of oxygen from small organic molecules represents a possible strategy to prevent cell death under anoxic conditions. A comprehensive study of methylated pyridone-derived endoperoxides has led to the development of water-soluble molecules that undergo retro Diels-Alder reactions in aqueous environment releasing oxygen in high yield and with half-lives of up to 13 hours.
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- Benz, Sebastian
- Noetzli, Sarah
- Siegel, Jay S
- Eberli, Daniel
- Jessen, Henning Jacob
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Benz, S., Noetzli, S., Siegel, J. S., Eberli, D., & Jessen, H. J. (2013). Controlled Oxygen Release from Pyridone Endoperoxides Promotes Cell Survival under Anoxic Conditions. Journal of Medicinal Chemistry, 56(24), 10171–10182. https://doi.org/10.1021/jm4016137
