Publication: Polypharmacy is Associated with an Increased Risk of Bleeding in Elderly Patients with Venous Thromboembolism
Polypharmacy is Associated with an Increased Risk of Bleeding in Elderly Patients with Venous Thromboembolism
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Leiss, W., Méan, M., Limacher, A., Righini, M., Jaeger, K., Beer, H.-J., Osterwalder, J., Frauchiger, B., Matter, C. M., Kucher, N., Angelillo-Scherrer, A., Cornuz, J., Banyai, M., Lämmle, B., Husmann, M., Egloff, M., Aschwanden, M., Rodondi, N., & Aujesky, D. (2015). Polypharmacy is Associated with an Increased Risk of Bleeding in Elderly Patients with Venous Thromboembolism. Journal of General Internal Medicine, 30(1), 17–24. https://doi.org/10.1007/s11606-014-2993-8
Abstract
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Abstract
BACKGROUND Polypharmacy, defined as the concomitant use of multiple medications, is very common in the elderly and may trigger drug-drug interactions and increase the risk of falls in patients receiving vitamin K antagonists. OBJECTIVE To examine whether polypharmacy increases the risk of bleeding in elderly patients who receive vitamin K antagonists for acute venous thromboembolism (VTE). DESIGN We used a prospective cohort study. PARTICIPANTS In a multicenter Swiss cohort, we studied 830 patients aged ≥ 65 years with VTE. MA
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- Leiss, Waltraud
- Méan, Marie
- Limacher, Andreas
- Righini, Marc
- Jaeger, Kurt
- Beer, Hans-Jürg
- Osterwalder, Joseph
- Frauchiger, Beat
- Matter, Christian M
- Kucher, Nils
- Angelillo-Scherrer, Anne
- Cornuz, Jacques
- Banyai, Martin
- Lämmle, Bernhard
- Husmann, Marc
- Egloff, Michael
- Aschwanden, Markus
- Rodondi, Nicolas
- Aujesky, Drahomir
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Leiss, W., Méan, M., Limacher, A., Righini, M., Jaeger, K., Beer, H.-J., Osterwalder, J., Frauchiger, B., Matter, C. M., Kucher, N., Angelillo-Scherrer, A., Cornuz, J., Banyai, M., Lämmle, B., Husmann, M., Egloff, M., Aschwanden, M., Rodondi, N., & Aujesky, D. (2015). Polypharmacy is Associated with an Increased Risk of Bleeding in Elderly Patients with Venous Thromboembolism. Journal of General Internal Medicine, 30(1), 17–24. https://doi.org/10.1007/s11606-014-2993-8
