Publication: The xeroderma pigmentosum pathway: decision tree analysis of DNA quality
The xeroderma pigmentosum pathway: decision tree analysis of DNA quality
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Naegeli, H., & Sugasawa, K. (2011). The xeroderma pigmentosum pathway: decision tree analysis of DNA quality. DNA Repair, 10, 673–683. https://doi.org/10.1016/j.dnarep.2011.04.019
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The nucleotide excision repair (NER) system is a fundamental cellular stress response that uses only a handful of DNA binding factors, mutated in the cancer-prone syndrome xeroderma pigmentosum (XP), to detect an astounding diversity of bulky base lesions, including those induced by ultraviolet light, electrophilic chemicals, oxygen radicals and further genetic insults. Several of these XP proteins are characterized by a mediocre preference for damaged substrates over the native double helix but, intriguingly, none of them recognizes
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- Naegeli, H
- Sugasawa, K
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Naegeli, H., & Sugasawa, K. (2011). The xeroderma pigmentosum pathway: decision tree analysis of DNA quality. DNA Repair, 10, 673–683. https://doi.org/10.1016/j.dnarep.2011.04.019
