Publication: From attention-deficit hyperactivity disorder to sporadic Alzheimer’s disease—Wnt/mTOR pathways hypothesis
From attention-deficit hyperactivity disorder to sporadic Alzheimer’s disease—Wnt/mTOR pathways hypothesis
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Grünblatt, E., Homolak, J., Babic Perhoc, A., Davor, V., Knezovic, A., Osmanovic Barilar, J., Riederer, P., Walitza, S., Tackenberg, C., & Salkovic-Petrisic, M. (2023). From attention-deficit hyperactivity disorder to sporadic Alzheimer’s disease—Wnt/mTOR pathways hypothesis. Frontiers in Neuroscience, 17, 1104985. https://doi.org/10.3389/fnins.2023.1104985
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Alzheimer’s disease (AD) is the most common neurodegenerative disorder with the majority of patients classified as sporadic AD (sAD), in which etiopathogenesis remains unresolved. Though sAD is argued to be a polygenic disorder, apolipoprotein E (APOE) ε4, was found three decades ago to pose the strongest genetic risk for sAD. Currently, the only clinically approved disease-modifying drugs for AD are aducanumab (Aduhelm) and lecanemab (Leqembi). All other AD treatment options are purely symptomatic with modest benefits. Similarly, att
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Grünblatt, E., Homolak, J., Babic Perhoc, A., Davor, V., Knezovic, A., Osmanovic Barilar, J., Riederer, P., Walitza, S., Tackenberg, C., & Salkovic-Petrisic, M. (2023). From attention-deficit hyperactivity disorder to sporadic Alzheimer’s disease—Wnt/mTOR pathways hypothesis. Frontiers in Neuroscience, 17, 1104985. https://doi.org/10.3389/fnins.2023.1104985