Publication: Immune cell-derived c3 is required for autoimmune diabetes induced by multiple low doses of streptozotocin
Immune cell-derived c3 is required for autoimmune diabetes induced by multiple low doses of streptozotocin
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Lin, M., Yin, N., Murphy, B., Medof, M. E., Segerer, S., Heeger, P. S., & Schröppel, B. (2010). Immune cell-derived c3 is required for autoimmune diabetes induced by multiple low doses of streptozotocin. Diabetes, 59(9), 2247–2252. https://doi.org/10.2337/db10-0044
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OBJECTIVE: The complement system contributes to autoimmune injury, but its involvement in promoting the development of autoimmune diabetes is unknown. In this study, our goal was to ascertain the role of complement C3 in autoimmune diabetes. RESEARCH DESIGN AND METHODS: Susceptibility to diabetes development after multiple low-dose streptozotocin treatment in wild-type (WT) and C3-deficient mice was analyzed. Bone marrow chimeras, luminex, and quantitative reverse transcription PCR assays were performed to evaluate the phenotypic and
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- Lin, Marvin
- Yin, Na
- Murphy, Barbara
- Medof, M Edward
- Segerer, Stephan
- Heeger, P S
- Schröppel, B
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Lin, M., Yin, N., Murphy, B., Medof, M. E., Segerer, S., Heeger, P. S., & Schröppel, B. (2010). Immune cell-derived c3 is required for autoimmune diabetes induced by multiple low doses of streptozotocin. Diabetes, 59(9), 2247–2252. https://doi.org/10.2337/db10-0044
