Effect of high glucose levels and lipopolysaccharides‐induced inflammation on osteoblast mineralization over sandblasted/acid‐etched titanium surface

Ramenzoni, Liza L; Bösch, Adrian; Proksch, Susanne; Attin, Thomas; Schmidlin, Patrick R

doi:10.1111/cid.12884

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Ramenzoni, L. L., Bösch, A., Proksch, S., Attin, T., & Schmidlin, P. R. (2020). Effect of high glucose levels and lipopolysaccharides‐induced inflammation on osteoblast mineralization over sandblasted/acid‐etched titanium surface. Clinical Implant Dentistry and Related Research, 22(2), 213–219. https://doi.org/10.1111/cid.12884

Abstract

Background and Purpose

Poorly controlled diabetes mellitus has been related to higher risk of implant treatment complications due to increased susceptibility to infection and delayed wound healing. Lipopolysaccharides (LPS) stimulate cytokine production leading to chronic inflammation and immunological host response that accentuates the destruction of periodontal tissues. This study aimed to evaluate the effect of different glycemic conditions on secretion and mineralization of bone matrix under sterile inflammation induced by LPS on