Publication: The relationship between CYP19A1 gene expression in luteinized granulosa cells and follicular estradiol output in women with endometriosis
The relationship between CYP19A1 gene expression in luteinized granulosa cells and follicular estradiol output in women with endometriosis
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Giacomini, E., Pagliardini, L., Minetto, S., Pinna, M., Kleeman, F., Bonesi, F., Makieva, S., Pavone, V., Reschini, M., Papaleo, E., Candiani, M., Somigliana, E., & Viganò, P. (2024). The relationship between CYP19A1 gene expression in luteinized granulosa cells and follicular estradiol output in women with endometriosis. Journal of Steroid Biochemistry and Molecular Biology, 237, 106439. https://doi.org/10.1016/j.jsbmb.2023.106439
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Endometriosis was claimed to negatively affect the intrafollicular environment, hindering oocyte competence. Previous studies evaluated expression levels of cytochrome P450 aromatase (CYP19A) in granulosa and cumulus oophorus cells collected from endometriosis women, but results are controversial. To further investigate the intrafollicular environment whose alteration may potentially disturb ovarian steroidogenesis in endometriosis, gene expression of CYP19A and of its upstream enzymes, StAR and 3βHSD was assessed in luteinized granul
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- Giacomini, Elisa
- Pagliardini, Luca
- Minetto, Sabrina
- Pinna, Monica
- Kleeman, Fabiola
- Bonesi, Francesca
- Makieva, Sofia
- Pavone, Valentina
- Reschini, Marco
- Papaleo, Enrico
- Candiani, Massimo
- Somigliana, Edgardo
- Viganò, Paola
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Giacomini, E., Pagliardini, L., Minetto, S., Pinna, M., Kleeman, F., Bonesi, F., Makieva, S., Pavone, V., Reschini, M., Papaleo, E., Candiani, M., Somigliana, E., & Viganò, P. (2024). The relationship between CYP19A1 gene expression in luteinized granulosa cells and follicular estradiol output in women with endometriosis. Journal of Steroid Biochemistry and Molecular Biology, 237, 106439. https://doi.org/10.1016/j.jsbmb.2023.106439
