Detection of Scedosporium spp.: Colonizer or pathogen? A retrospective analysis of clinical significance and management in a large tertiary centre

Reinhold, Ilana; Quiblier, Chantal; Blaser, Frank; Bögeholz, Jan; Imkamp, Frank; Schuurmans, Macé M; Soyka, Michael B; Zbinden, Reinhard; Mueller, Nicolas J

doi:10.1093/mmy/myae002

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Reinhold, I., Quiblier, C., Blaser, F., Bögeholz, J., Imkamp, F., Schuurmans, M. M., Soyka, M. B., Zbinden, R., & Mueller, N. J. (2024). Detection of Scedosporium spp.: Colonizer or pathogen? A retrospective analysis of clinical significance and management in a large tertiary centre. Medical Mycology, 62(2), myae002. https://doi.org/10.1093/mmy/myae002

Abstract

Infections with Scedosporium spp. are emerging in the past two decades and are associated with a high mortality rate. Microbiological detection can be associated with either a colonization or infection. Evolution from colonization into infection is difficult to predict and clinical management upon microbiological detection is complex. Microbiological samples from 2015 to 2021 were retrospectively analyzed in a single tertiary care centre. Classification into colonization or infection was performed upon first microbiological detection.