Publication: Altered neuroaxonal integrity in schizophrenia and major depressive disorder assessed with neurofilament light chain in serum
Altered neuroaxonal integrity in schizophrenia and major depressive disorder assessed with neurofilament light chain in serum
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Bavato, F., Cathomas, F., Klaus, F., Gütter, K., Barro, C., Maceski, A., Seifritz, E., Kuhle, J., Kaiser, S., & Quednow, B. B. (2021). Altered neuroaxonal integrity in schizophrenia and major depressive disorder assessed with neurofilament light chain in serum. Journal of Psychiatric Research, 140, 141–148. https://doi.org/10.1016/j.jpsychires.2021.05.072
Abstract
Abstract
Abstract
Background
Schizophrenia (SZ) and major depressive disorders (MDD) have been frequently linked to anatomical brain alterations. However, the relationship between brain pathology, inflammation and clinical symptoms in these disorders is still unclear. Thus, by applying novel blood markers of neuroaxonal integrity such as neurofilament light chain (NfL), we can now address main issues in psychiatric research and potentially offer innovative diagnostic tools toward better clinical characterizations and monitoring in both SZ and MDD. Met
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Creators (Authors)
- Bavato, Francesco
- Cathomas, Flurin
- Klaus, Federica
- Gütter, Karoline
- Barro, Christian
- Maceski, Aleksandra
- Seifritz, Erich
- Kuhle, Jens
- Kaiser, Stefan
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Bavato, F., Cathomas, F., Klaus, F., Gütter, K., Barro, C., Maceski, A., Seifritz, E., Kuhle, J., Kaiser, S., & Quednow, B. B. (2021). Altered neuroaxonal integrity in schizophrenia and major depressive disorder assessed with neurofilament light chain in serum. Journal of Psychiatric Research, 140, 141–148. https://doi.org/10.1016/j.jpsychires.2021.05.072
