Publication: Mutation of vsx genes in zebrafish highlights the robustness of the retinal specification network
Mutation of vsx genes in zebrafish highlights the robustness of the retinal specification network
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Letelier, J., Buono, L., Almuedo-Castillo, M., Zang, J., Mounieres, C., González-Díaz, S., Polvillo, R., Sanabria-Reinoso, E., Corbacho, J., Sousa-Ortega, A., Del Corral, R. D., Neuhauss, S. C. F., & Martínez-Morales, J. R. (2023). Mutation of vsx genes in zebrafish highlights the robustness of the retinal specification network. ELife, 12, e85594. https://doi.org/10.7554/eLife.85594
Abstract
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Abstract
Genetic studies in human and mice have established a dual role for Vsx genes in retina development: an early function in progenitors' specification, and a later requirement for bipolar-cells fate determination. Despite their conserved expression patterns, it is currently unclear to which extent Vsx functions are also conserved across vertebrates, as mutant models are available only in mammals. To gain insight into vsx function in teleosts, we have generated vsx1 and vsx2 CRISPR/Cas9 double knockouts (vsxKO) in zebrafish. Our electroph
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- Letelier, Joaquín
- Buono, Lorena
- Almuedo-Castillo, María
- Zang, Jingjing
- Mounieres, Constanza
- González-Díaz, Sergio
- Polvillo, Rocío
- Sanabria-Reinoso, Estefanía
- Corbacho, Jorge
- Sousa-Ortega, Ana
- Del Corral, Ruth Diez
- Martínez-Morales, Juan R
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Letelier, J., Buono, L., Almuedo-Castillo, M., Zang, J., Mounieres, C., González-Díaz, S., Polvillo, R., Sanabria-Reinoso, E., Corbacho, J., Sousa-Ortega, A., Del Corral, R. D., Neuhauss, S. C. F., & Martínez-Morales, J. R. (2023). Mutation of vsx genes in zebrafish highlights the robustness of the retinal specification network. ELife, 12, e85594. https://doi.org/10.7554/eLife.85594
