Publication: Replicated chromatin curtails 53BP1 recruitment in BRCA1-proficient and BRCA1-deficient cells
Replicated chromatin curtails 53BP1 recruitment in BRCA1-proficient and BRCA1-deficient cells
Date
Date
Date
Citations
Michelena, J., Pellegrino, S., Spegg, V., & Altmeyer, M. (2021). Replicated chromatin curtails 53BP1 recruitment in BRCA1-proficient and BRCA1-deficient cells. Life Science Alliance, 4(6), e202101023. https://doi.org/10.26508/lsa.202101023
Abstract
Abstract
Abstract
DNA double-strand breaks can be repaired by non-homologous end-joining or homologous recombination. Which pathway is used depends on the balance between the tumor suppressors 53BP1 and BRCA1 and on the availability of an undamaged template DNA for homology-directed repair. How cells switch from a 53BP1-dominated to a BRCA1-governed homologous recombination response as they progress through the cell cycle is incompletely understood. Here we reveal, using high-throughput microscopy and applying single cell normalization to control for i
Metrics
Downloads
Views
Additional indexing
Creators (Authors)
- Michelena, Jone
- Pellegrino, Stefania
- Spegg, Vincent
- Altmeyer, Matthias
Volume
Volume
Volume
Number
Number
Number
Page range/Item number
Page range/Item number
Page range/Item number
Item Type
Item Type
Item Type
Keywords
Language
Language
Language
Publication date
Publication date
Publication date
Date available
Date available
Date available
ISSN or e-ISSN
ISSN or e-ISSN
ISSN or e-ISSN
OA Status
OA Status
OA Status
Free Access at
Free Access at
Free Access at
Publisher DOI
Metrics
Downloads
Views
Citations
Michelena, J., Pellegrino, S., Spegg, V., & Altmeyer, M. (2021). Replicated chromatin curtails 53BP1 recruitment in BRCA1-proficient and BRCA1-deficient cells. Life Science Alliance, 4(6), e202101023. https://doi.org/10.26508/lsa.202101023
