Publication: Modeling the effect of HIV coinfection on clearance and sustained virologic response during treatment for hepatitis C virus
Modeling the effect of HIV coinfection on clearance and sustained virologic response during treatment for hepatitis C virus
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Birger, R., Kouyos, R., Dushoff, J., & Grenfell, B. (2015). Modeling the effect of HIV coinfection on clearance and sustained virologic response during treatment for hepatitis C virus. Epidemics, 12, 1–10. https://doi.org/10.1016/j.epidem.2015.04.001
Abstract
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Abstract
Background: HIV/hepatitis C (HCV) coinfection is a major concern in global health today. Each pathogen can exacerbate the effects of the other and affect treatment outcomes. Understanding the within-host dynamics of these coinfecting pathogens is crucial, particularly in light of new, direct-acting antiviral agents (DAAs) for HCV treatment that are becoming available. Methods and findings: In this study, we construct a within-host mathematical model of HCV/HIV coinfection by adapting a previously published model of HCV monoinfection t
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- Birger, Ruthie
- Kouyos, Roger
- Dushoff, Jonathan
- Grenfell, Bryan
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Birger, R., Kouyos, R., Dushoff, J., & Grenfell, B. (2015). Modeling the effect of HIV coinfection on clearance and sustained virologic response during treatment for hepatitis C virus. Epidemics, 12, 1–10. https://doi.org/10.1016/j.epidem.2015.04.001
