Abnormal respiration under hyperoxia in TASK-1/3 potassium channel double knockout mice

Buehler, Philipp K; Bleiler, Doris; Tegtmeier, Ines; Heitzmann, Dirk; Both, Christian; Georgieff, Michael; Lesage, Florian; Warth, Richard; Thomas, Jörg

doi:10.1016/j.resp.2017.06.009

Citations

Citation copied

Buehler, P. K., Bleiler, D., Tegtmeier, I., Heitzmann, D., Both, C., Georgieff, M., Lesage, F., Warth, R., & Thomas, J. (2017). Abnormal respiration under hyperoxia in TASK-1/3 potassium channel double knockout mice. Respiratory Physiology & Neurobiology, 244, 17–25. https://doi.org/10.1016/j.resp.2017.06.009

Abstract

Despite intensive research, the exact function of TASK potassium channels in central and peripheral chemoreception is still under debate. In this study, we investigated the respiration of unrestrained TASK-3 (TASK-3(-/-)) and TASK-1/TASK-3 double knockout (TASK-1/3(-/-)) adult male mice in vivo using a plethysmographic device. Ventilation parameters of TASK-3(-/-) mice were normal under control condition (21% O2) and upon hypoxia and hypercapnia they displayed the physiological increase of ventilation. TASK-1/3(-/-) mice showed increa