Publication: Antiviral Activity of HIV gp120-Targeting Bispecific T Cell Engager Antibody Constructs
Antiviral Activity of HIV gp120-Targeting Bispecific T Cell Engager Antibody Constructs
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Brozy, J., Schlaepfer, E., Mueller, C. K. S., Rochat, M.-A., Rampini, S. K., Myburgh, R., Raum, T., Kufer, P., Baeuerle, P. A., Muenz, M., & Speck, R. F. (2018). Antiviral Activity of HIV gp120-Targeting Bispecific T Cell Engager Antibody Constructs. Journal of Virology, 92(14), 1–13. https://doi.org/10.1128/JVI.00491-18
Abstract
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Abstract
Today's gold standard in HIV therapy is combined antiretroviral therapy (cART). It requires strict adherence by patients and lifelong medication, which can lower the viral load below detection limits and prevent HIV-associated immunodeficiency but cannot cure patients. The bispecific T cell-engaging (BiTE) antibody technology has demonstrated long-term relapse-free outcomes in patients with relapsed and refractory acute lymphocytic leukemia. Here, we generated BiTE antibody constructs that target the HIV-1 envelope protein gp120 (HIV
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- Brozy, Johannes
- Schlaepfer, Erika
- Mueller, Christina K S
- Rochat, Mary-Aude
- Rampini, Silvana K
- Myburgh, Renier
- Raum, Tobias
- Kufer, Peter
- Baeuerle, Patrick A
- Muenz, Markus
- Speck, Roberto F
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Brozy, J., Schlaepfer, E., Mueller, C. K. S., Rochat, M.-A., Rampini, S. K., Myburgh, R., Raum, T., Kufer, P., Baeuerle, P. A., Muenz, M., & Speck, R. F. (2018). Antiviral Activity of HIV gp120-Targeting Bispecific T Cell Engager Antibody Constructs. Journal of Virology, 92(14), 1–13. https://doi.org/10.1128/JVI.00491-18
