Publication: Localization and production of peptide endocannabinoids in the rodent CNS and adrenal medulla
Localization and production of peptide endocannabinoids in the rodent CNS and adrenal medulla
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Hofer, S. C., Ralvenius, W. T., Gachet, M. S., Fritschy, J.-M., Zeilhofer, H. U., & Gertsch, J. (2015). Localization and production of peptide endocannabinoids in the rodent CNS and adrenal medulla. Neuropharmacology, 98, 78–89. https://doi.org/10.1016/j.neuropharm.2015.03.021
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The endocannabinoid system (ECS) comprises the cannabinoid receptors CB1 and CB2 and their endogenous arachidonic acid-derived agonists 2-arachidonoyl glycerol and anandamide, which play important neuromodulatory roles. Recently, a novel class of negative allosteric CB1 receptor peptide ligands, hemopressin-like peptides derived from alpha hemoglobin, has been described, with yet unknown origin and function in the CNS. Using monoclonal antibodies we now identified the localization of RVD-hemopressin (pepcan-12) and N-terminally extend
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- Hofer, Stefanie C
- Ralvenius, William T
- Gachet, M Salomé
- Fritschy, Jean-Marc
- Gertsch, Jürg
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Hofer, S. C., Ralvenius, W. T., Gachet, M. S., Fritschy, J.-M., Zeilhofer, H. U., & Gertsch, J. (2015). Localization and production of peptide endocannabinoids in the rodent CNS and adrenal medulla. Neuropharmacology, 98, 78–89. https://doi.org/10.1016/j.neuropharm.2015.03.021
