Publication: Homeostatic maintenance of T cells and natural killer cells
Homeostatic maintenance of T cells and natural killer cells
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Boyman, O., Krieg, C., Homann, D., & Sprent, J. (2012). Homeostatic maintenance of T cells and natural killer cells. Cellular and Molecular Life Sciences, 69, 1597–1608. https://doi.org/10.1007/s00018-012-0968-7
Abstract
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Homeostasis in the immune system encompasses the mechanisms governing maintenance of a functional and diverse pool of lymphocytes, thus guaranteeing immunity to pathogens while remaining self-tolerant. Antigen-naïve T cells rely on survival signals through contact with self-peptide-loaded major histocompatibility complex (MHC) molecules plus interleukin (IL)-7. Conversely, antigen-experienced (memory) T cells are typically MHC-independent and they survive and undergo periodic homeostatic proliferation through contact with both IL-7 an
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- Boyman, Onur
- Krieg, Carsten
- Homann, Dirk
- Sprent, Jonathan
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Boyman, O., Krieg, C., Homann, D., & Sprent, J. (2012). Homeostatic maintenance of T cells and natural killer cells. Cellular and Molecular Life Sciences, 69, 1597–1608. https://doi.org/10.1007/s00018-012-0968-7
