Publication: Polarized expression of drug transporters in differentiated human hepatoma HepaRG cells
Polarized expression of drug transporters in differentiated human hepatoma HepaRG cells
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Le Vee, M., Noel, G., Jouan, E., Stieger, B., & Fardel, O. (2013). Polarized expression of drug transporters in differentiated human hepatoma HepaRG cells. Toxicology in Vitro, 27(6), 1979–1986. https://doi.org/10.1016/j.tiv.2013.07.003
Abstract
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The HepaRG cell line is a well-differentiated human hepatoma cell line proposed as a surrogate for human hepatocytes, especially for hepatic detoxification studies. Polarized status of drug transporters, i.e., their coordinated location at sinusoidal or canalicular membranes, which represents a key hallmark of hepato-biliary drug transport, remains however incompletely documented in HepaRG cells. The present study was therefore designed to analyze transporter location in HepaRG cells, which exhibit mRNA expressions of most of hepatic
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- Le Vee, Marc
- Noel, Gregory
- Jouan, Elodie
- Stieger, Bruno
- Fardel, Olivier
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Le Vee, M., Noel, G., Jouan, E., Stieger, B., & Fardel, O. (2013). Polarized expression of drug transporters in differentiated human hepatoma HepaRG cells. Toxicology in Vitro, 27(6), 1979–1986. https://doi.org/10.1016/j.tiv.2013.07.003
