Publication: NG2 glia protect against prion neurotoxicity by inhibiting microglia-to-neuron prostaglandin E2 signaling
NG2 glia protect against prion neurotoxicity by inhibiting microglia-to-neuron prostaglandin E2 signaling
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Liu, Y., Guo, J., Matoga, M., Korotkova, M., Jakobsson, P.-J., & Aguzzi, A. (2024). NG2 glia protect against prion neurotoxicity by inhibiting microglia-to-neuron prostaglandin E2 signaling. Nature Neuroscience, 27, 1534–1544. https://doi.org/10.1038/s41593-024-01663-x
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Oligodendrocyte-lineage cells, including NG2 glia, undergo prominent changes in various neurodegenerative disorders. Here, we identify a neuroprotective role for NG2 glia against prion toxicity. NG2 glia were activated after prion infection in cerebellar organotypic cultured slices (COCS) and in brains of prion-inoculated mice. In both model systems, depletion of NG2 glia exacerbated prion-induced neurodegeneration and accelerated prion pathology. Loss of NG2 glia enhanced the biosynthesis of prostaglandin E2 (PGE2) by microglia, whic
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- Liu, Yingjun
- Guo, Jingjing
- Matoga, Maja
- Korotkova, Marina
- Jakobsson, Per-Johan
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Liu, Y., Guo, J., Matoga, M., Korotkova, M., Jakobsson, P.-J., & Aguzzi, A. (2024). NG2 glia protect against prion neurotoxicity by inhibiting microglia-to-neuron prostaglandin E2 signaling. Nature Neuroscience, 27, 1534–1544. https://doi.org/10.1038/s41593-024-01663-x
