Publication: Urinary proteomic diagnosis of coronary artery disease: identification and clinical validation in 623 individuals
Urinary proteomic diagnosis of coronary artery disease: identification and clinical validation in 623 individuals
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Delles, C., Schiffer, E., von Zur Muhlen, C., Peter, K., Rossing, P., Parving, H. H., Dymott, J. A., Neisius, U., Zimmerli, L. U., Snell-Bergeon, J. K., Maahs, D. M., Schmieder, R. E., Mischak, H., & Dominiczak, A. F. (2010). Urinary proteomic diagnosis of coronary artery disease: identification and clinical validation in 623 individuals. Journal of Hypertension, 28(11), 2316–2322. https://doi.org/10.1097/HJH.0b013e32833d81b7
Abstract
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OBJECTIVES: We studied the urinary proteome in a total of 623 individuals with and without coronary artery disease (CAD) in order to characterize multiple biomarkers that enable prediction of the presence of CAD.
METHODS: Urine samples were analyzed by capillary electrophoresis coupled online to micro time-of-flight mass spectrometry.
RESULTS: We defined a pattern of 238 CAD-specific polypeptides from comparison of 586 spot urine samples from 408 individuals. This pattern identified patients with CAD in a blinded cohort of 138 urine
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- Delles, C
- Schiffer, E
- von Zur Muhlen, C
- Peter, K
- Rossing, P
- Parving, H H
- Dymott, J A
- Neisius, U
- Zimmerli, L U
- Snell-Bergeon, J K
- Maahs, D M
- Schmieder, R E
- Mischak, H
- Dominiczak, A F
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Delles, C., Schiffer, E., von Zur Muhlen, C., Peter, K., Rossing, P., Parving, H. H., Dymott, J. A., Neisius, U., Zimmerli, L. U., Snell-Bergeon, J. K., Maahs, D. M., Schmieder, R. E., Mischak, H., & Dominiczak, A. F. (2010). Urinary proteomic diagnosis of coronary artery disease: identification and clinical validation in 623 individuals. Journal of Hypertension, 28(11), 2316–2322. https://doi.org/10.1097/HJH.0b013e32833d81b7