Cortical miR-709 links glutamatergic signaling to NREM sleep EEG slow waves in an activity-dependent manner

Kompotis, Konstantinos; Mang, Géraldine M; Hubbard, Jeffrey; Jimenez, Sonia; Emmenegger, Yann; Polysopoulos, Christos; Hor, Charlotte N; Wigger, Leonore; Hébert, Sébastien S; Mongrain, Valérie; Franken, Paul

doi:10.1073/pnas.2220532121

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Kompotis, K., Mang, G. M., Hubbard, J., Jimenez, S., Emmenegger, Y., Polysopoulos, C., Hor, C. N., Wigger, L., Hébert, S. S., Mongrain, V., & Franken, P. (2024). Cortical miR-709 links glutamatergic signaling to NREM sleep EEG slow waves in an activity-dependent manner. Proceedings of the National Academy of Sciences of the United States of America, 121(3), e2220532121. https://doi.org/10.1073/pnas.2220532121

Abstract

MicroRNAs (miRNAs) are key post-transcriptional regulators of gene expression that have been implicated in a plethora of neuronal processes. Nevertheless, their role in regulating brain activity in the context of sleep has so far received little attention. To test their involvement, we deleted mature miRNAs in post-mitotic neurons at two developmental ages, i.e., in early adulthood using conditional Dicer knockout (cKO) mice and in adult mice using an inducible conditional Dicer cKO (icKO) line. In both models, electroencephalographic